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Cannabinol, or CBN for short, is a molecule derived from hemp that is reputed to have exceptional relaxing and sedative properties. Although it occurs in much lesser concentration than its more famous sister phytocannabinoids, CBN is considered one of the “Big Six,” the most notable of over 100 identified to date.
As depicted below, a series of chemical changes within the hemp plant leads to the existence of phytocannabinoids usable by the human body. All derive from CBGa, the “mother” who plays a pivotal role in their synthesis and the overall composition of the plant. However, CBN’s origin is unique: It is a byproduct of the breakdown of other plant compounds. Technically, there are multiple pathways to CBN, but exposure to environmental factors like heat, UV light and time are nature’s way of creating CBN.
How does CBN work?
Within the human body, CBN interacts with receptors in the endocannabinoid system (ECS) located in the central nervous system and throughout the body. Phytocannabinoids like CBN are thought to mimic the body’s own endocannabinoids by “filling in” on the duties of physiological signaling.
CBN can bind to both CB1 and CB2 receptors in the ECS. CB1 receptor activation can result in sedation and increased sleep, and CBN binds pretty well to CB1 receptors. CBN is a partial “agonist,” which is a substance that binds with a receptor to initiate a physiological response. CBN has an active metabolite (called 11-OH-CBN) that is a more potent receptor agonist.
CBN also contributes to the “entourage effect.” This phenomenon explains that the total effect of the whole plant, which include terpenes and other compounds not yet fully understood, is greater than the sum of its parts.
This concept is well-understood when discussing whole foods versus processed foods or a cup of coffee versus pure caffeine. Which provides the better overall experience?
What are the benefits of CBN?
While studies regarding the full scope of its benefits are still growing, CBN is most closely associated with good rest. It was originally thought to be euphorigenic like its more-famous chemical parent, but CBN is now known to produce only mild euphorigenic effects and has become more renowned for its sedative properties.
Anecdotal evidence posits that the most promising area of benefit may be evening relaxation and better overall restfulness, while some scientific research suggests it may work synergistically with its chemical parent to calm and uplift the mind.
Clinical studies of CBN are very limited. It has been indicated as a sedative and, in studies, has demonstrated anti-convulsant, appetite stimulation and anti-inflammatory effects, especially alongside other phytocannabinoids.
How does the body process CBN?
The human body has multiple ways of metabolizing substances, including the liver and the GI (gastrointestinal) tract.
How a substance is ingested can affect how much of it remains “bioavailable” and how quickly it is metabolized. Bioavailability refers to the amount of an active substance that is allowed into the bloodstream while remaining active. For example, a swallowed pill may have less bioavailability than a sublingual tincture, which has a more direct route to the circulatory system; and an an inhaled substance has even greater bioavailability because it bypasses first-pass metabolism by the liver and GI system.
So the answer is: It depends on the form factor and method of ingestion. But once an active compound hits the circulatory system, it is routed to ECS receptors as needed.
Proper sleep hygiene can go a long way toward improving your rest and reaping the benefits of good sleep. But sometimes it’s not enough. BLOOM FARMS Dream CBN Tincture was designed for supreme evening relaxation.
Some people have reported tiredness, drowsiness, dizziness, loss of appetite and euphoria. Depending on an individual’s desired outcomes, most of these potential side effects are either expected or may not be perceived as negative effects.
Possible signs of taking too much CBN include feeling groggy after getting a full night’s sleep or experiencing abnormally vivid dreams, dizziness or headache. Possible indicators of not taking enough CBN include continued trouble falling asleep within 20-30 minutes, trouble staying asleep and difficulty getting back to sleep after waking up briefly (i.e., going to the bathroom).
Can CBN be used with alcohol or medications?
Some ingredients in CBN products can both inactivate and enhance various (P450) enzymes in the liver, which can potentially impact a wide range of medications.
CBN, other phytocannabinoids and even herbal remedies can affect cardiac and blood pressure medications, blood thinners, immunosuppresive drugs and antipsychotic medications to name a few.
It’s important to note that one person might not respond to a particular compound or combination of substances (including herbs) the same was as another person. Some factors that contribute to how we respond include: genetic makeup, ethnic background, sex, liver and kidney function, diseases, nutritional state, age and even method of ingestion. Also, elderly people, people with certain medical conditions and those ingesting alcohol may carry greater risks because of reduced liver and kidney function, which contribute to metabolization of substances.
As with all medications, phytocannabinoids or herbal remedies, we always recommend consulting with a trusted medical profession for guidance related to your specific conditions and medications.
“I've been having sleep issues on and off for the past few months. I've dabbled with taking melatonin and other sleep aids—which have helped in ways—but have yet to find a real solution that I trust on a consistent or as-needed basis... until now. DREAM has been nothing short of amazing, truly living up to its name.” —Max Karp
Dream 1200 mg 5:1 CBN Tincture
Mini 10 ml Dream 5:1 CBN Tincture
Dream 5:1 CBN Mini Vapor Pen – 0.5 g
Dream 5:1 CBN Vapor Cartridge - 0.5 g
Bloom Farms Dream CBN Tincture
Pure, simple Bloom Farms Dream CBN Tincture was designed to encourage the rest and relaxation of whole-plant hemp extract—plus potent CBN for a boosted sedative effect. Users report that they:
My biggest issue was staying asleep throughout the night and this has helped me so much! Im finally sleeping so well all night long and waking up feeling refreshed!
As an athlete who is still training, sleep is an imperative part of my recovery process. The Dream Tincture has been the best tool I have found to get me into a deep sleep cycle that is allowing me to recover and perform effectively.
I did not think I would notice as big as a difference as I did! I am sleeping un-interrupted for the first time in a long time and waking up refreshed everyday.
My sleep schedule got off because of quarantine, the Dream tincture helped me regulate my sleep and fix my schedule.
I fall asleep quickly with no tossing and turning. I used to wake up frequently through the night, but with the Dream tincture I sleep through until morning. I absolutely love this product.
I’ve used this tincture on nights I have trouble sleeping and it has helped me relax so much! The directions on how much to take are clear and the packaging is beautiful :)
Bloom Farms Dream CBN Vapor
Pure, all-natural uncut whole-plant hemp extract is enhanced with potent CBN and a solventless full-spectrum terpene blend that borrows notes from Roman chamomile, valerian and lavender.
The CBN makes a huge difference in helping me get to sleep at night. Works every time!
I take a 1/4 dropper and sleep like a baby, wake up feeling refreshed! I love it.
The Dream tincture was great! Sometimes I have trouble sleeping, and this helped me to fall asleep, and stay asleep without feeling groggy in the morning!
This tincture is honestly the best sleep aid I've tried compared to other tinctures or tablets out on the market. Like all other Bloom Farms products, the new Dream tincture is extremely high quality.
My husband and I both love this tincture. I noticed that I was able to get to sleep faster and stay asleep with this tincture.
I recently tried the Dream and immediately knew this would be my new go-to. Threw out the melatonin and valerian root and now use this exclusively. The relaxed feeling it gives me helps me slip right into sleep!